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The Regional HIV/AIDS Prevention and Care project, known in west Africa as PACTE-VIH, addresses the critical gaps in programming for key populations — specifically female sex workers and their clients, and men who have sex with men — across west Africa. As part of project closeout (July 2017), PACTE-VIH developed an "insight" series of lessons learned throughout five years of implementation. This resource highlights the background, outcomes, challenges, lessons learned, and recommendations for implementing mHealth programming for HIV prevention with key populations.