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This document: (1) outlines the acceleration initiative; (2) describes the process and the progress made under it using examples from four countries: Côte d’Ivoire, Democratic Republic of the Congo (DRC), Malawi, and South Sudan; and (3) discusses some of the lessons learned. This information may be of interest to those designing and implementing programs for HIV or other diseases, including public health officials and program managers, civil society organizations, advocates, funding agencies, and policymakers.